Episódios de MFCê Podcast

Anemia no hemograma: O que investigar antes de prescrever ferro? | MFCê #10

10 de setembro de 202627min
0:00 / 27:43

Você já atendeu um paciente com anemia no hemograma e ficou na dúvida se era hora de suplementar ferro ou aprofundar a investigação? E se a anemia microcítica não for necessariamente deficiência de ferro?

Neste episódio de MFCê, conversamos com a médica de família e comunidade Dra. Janine Castro sobre a investigação inicial das anemias na Atenção Primária. A partir de um caso clínico prático, discutimos como interpretar índices como VCM, RDW e ferritina, o que perguntar na anamnese para identificar perdas sanguíneas e quais exames solicitar antes de definir a conduta no SUS.

Referências discutidas no episódio:

⁠https://www.acpjournals.org/doi/10.7326/A22-0007⁠

Burack WR, Lichtman MA. The Complete Blood Count: Increasing Its Precision and Impact. Ann Intern Med. 2023;176(3):404-405. doi:10.7326/M22-3071 

Go LT, Go LT, Gunaratne MDSK, Abeykoon JP. Variation in Complete Blood Count Reports Across US Hospitals. JAMA Netw Open. 2025;8(6):e2514050. Published 2025 Jun 2. doi:10.1001/jamanetworkopen.2025.14050 

Burack WR, Lichtman MA. The Complete Blood Count-Time to Assess What Is Impactful and What Is Distracting. JAMA Netw Open. 2025;8(6):e2514055. Published 2025 Jun 2. doi:10.1001/jamanetworkopen.2025.14055 

Lichtman MA, Burack RW. The evolution of the complete blood count: have we gone too far?. Haematologica. 2026;111(4):1215-1219. doi:10.3324/haematol.2025.300032

Symptom to Diagnosis. 4ª ed. Cap. 6, Anemia

Iolascon A, et al. Recommendations for diagnosis, treatment, and prevention of iron deficiency and iron deficiency anemia. Hemasphere. 2024.

Buttarello M, et al. Evaluation of the hypochromic erythrocyte and reticulocyte hemoglobin content... Clin Chem Lab Med. 2016.

Ko CW, Siddique SM, Patel A, et al. AGA Clinical Practice Guidelines on the Gastrointestinal Evaluation of Iron Deficiency Anemia. Gastroenterology. 2020;159(3):1085-1094.

DeLoughery TG, et al. AGA clinical practice update on management of iron deficiency anemia: expert review. Clin Gastroenterol Hepatol. 2024.

Thurnham DI, et al. Adjusting plasma ferritin concentrations to remove the effects of subclinical inflammation... Am J Clin Nutr. 2010.

Stoffel NU, Cercamondi CI, Brittenham G, et al. Iron absorption from oral iron supplements given on consecutive versus alternate days... Lancet Haematol. 2017.

Stoffel NU, Zeder C, Brittenham GM, et al. Iron absorption from supplements is greater with alternate day than with consecutive day dosing in iron-deficient anemic women. Haematologica. 2020;105(5):1232-1239.

Tolkien Z, Stecher L, Mander AP, Pereira DIA, Powell JJ. Ferrous sulfate supplementation causes significant gastrointestinal side-effects in adults: a systematic review and meta-analysis. PLoS One. 2015;10(2):e0117383.

Kalra PR, Cleland JGF, Petrie MC, et al. Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN). Lancet. 2022;400(10369):2199-2209.

Zoller H, Wolf M, Blumenstein I, et al. Hypophosphataemia following ferric derisomaltose and ferric carboxymaltose... (PHOSPHARE-IBD). Gut. 2023;72(4):644-653.

US Preventive Services Task Force; Nicholson WK, et al. Screening and supplementation for iron deficiency and iron deficiency anemia during pregnancy: USPSTF recommendation statement. JAMA. 2024;332(11):906-913.

NICE Clinical Knowledge Summaries / NHS primary care anaemia pathways (várias fontes regionais NHS).

McGee S. Evidence-Based Physical Diagnosis. 5th ed. Elsevier; 2021 — Capítulo 10: Anemia (dados de razão de verossimilhança para sinais de palidez).

Estudos de acurácia diagnóstica de RDW/VCM em pediatria e adolescência (PLOS Global Public Health, 2025; PMC, estudos em crianças 1-3 anos).